[Vogelstein, Bert, Kinzler, Kenneth, Parsons, Williams, Zhang, Xiaosong, Lin, Jimmy Cheng-Ho, Leary, Rebecca, Angenendt, Philipp, Papadopoulos, Nickolas, Velculescu, Victor, Parmigiani, Giovanni, Karchin, Rachel, Jones, Sian, Yan, Hai, Bigner, Darell, Kuan, Chien-Tsun, Riggins, Gregory]

[VOGELSTEIN BERT, KINZLER KENNETH W, PARSONS D WILLIAMS, ZHANG XIAOSONG, LIN JIMMY CHENG-HO, LEARY REBECCA J, ANGENENDT PHILIPP, PAPADOPOULOS NICKOLAS, VELCULESCU VICTOR, PARMIGIANI GIOVANNI, KARCHIN RACHEL, JONES SIAN, YAN HAI, BIGNER DARELL, KUAN CHIEN-TSUN, RIGGINS GREGORY J] US;US

[ANGENENDT, Georg, KAIRIES, Kai-Philipp] Jülicher Str. 72a52070 Aachen A method for the early detection of critical faults in a battery (4, 5, 6), following putting into service and during battery operation of the battery (4, 5, 6), comprises receiving battery data, provided by a battery management system, BMS (2), associated with the battery (4, 5, 6), at a remote diagnostic unit (3), wherein the battery data relate, in terms of time, to electrical properties of the battery (4, 5, 6) that are measured during battery operation; and carrying out remote diagnosis of the battery (4, 5, 6) through phased comparison and/or cyclic comparison of the received battery data with reference battery data, wherein a phase is one of: a charging phase, a transition phase and a discharging phase in relation to the battery operation, and wherein a cycle comprises successive phases of the charging phase, the transition phase and the discharging phase. A method for the early detection of critical faults in a battery (4, 5, 6), following putting into service and during battery operation of the battery (4, 5, 6), comprises receiving battery data, provided by a battery management system, BMS (2), associated with the battery (4, 5, 6), at a remote diagnostic unit (3), wherein the battery data relate, in terms of time, to electrical properties of the battery (4, 5, 6) that are measured during battery operation; and carrying out remote diagnosis of the battery (4, 5, 6) through phased comparison and/or cyclic comparison of the received battery data with reference battery data, wherein a phase is one of: a charging phase, a transition phase and a discharging phase in relation to the battery operation, and wherein a cycle comprises successive phases of the charging phase, the transition phase and the discharging phase.

[KAIRIES, Kai-Philipp, ANGENENDT, Georg, KUIPERS, Matthias] Jülicher Str. 72a52070 Aachen A method (S200) for quality testing of a battery is disclosed. The method (S200) comprising performing (S210) a battery formation process on the battery; acquiring (S220) data of the battery from the battery formation process, and the data of the battery temporally relates electrical characteristics of the battery; and quality testing (S230) of the battery by phase-wise comparing and/or cycle-wise comparing the acquired data with reference battery data, and a phase is one of: a charge phase, a transitional phase and a discharge phase of the battery formation process, and a cycle comprises consecutive phases of the charge phase, the transitional phase and the discharge phase.

[Vogelstein, Bert, Kinzler, Kenneth, Parsons, Williams, Zhang, Xiaosong, Lin, Jimmy Cheng-Ho, Leary, Rebecca, Angenendt, Philipp, Papadopoulos, Nickolas, Velculescu, Victor, Parmigiani, Giovanni, Karchin, Rachel, Jones, Sian, Yan, Hai, Bigner, Darell, Kuan, Chien-Tsun, Riggins, Gregory] 3400 N. Charles Street, Baltimore, MD 21218, US

[VOGELSTEIN BERT, KINZLER KENNETH W, PARSONS D WILLIAMS, ZHANG XIAOSONG, LIN JIMMY CHANG-HO, LEARY REBECCA J, ANGENENDT PHILIPP, PAPADOPOULOS NICKOLAS, VELCULESCU VICTOR, PARMIGIANI GIOVANNI, KARCHIN RACHEL, JONES SIAN, YAN HAI, BIGNER DARELL, KUAN CHIEN-TSUN] ;

[HAI YAN, BERT VOGELSTEIN, KENNETH W KINZLER, D WILLIAMS PARSONS, XIAOSONG ZHANG, REBECCA J LEARY, PHILIPP ANGENENDT, NICKOLAS PAPADOPOULOS, VICTOR VELCULESCU, GIOVANNI PARMIGIANI, RACHEL KARCHIN, SIAN JONES, DARELL BIGNER, CHIEN-TSUN KUAN, JIMMY CHENG-HO LIN, GREGORY RIGGINS] US We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.

[VOGELSTEIN BERT, KINZLER KENNETH, PARSONS WILLIAMS, ZHANG XIAOSONG, LIN JIMMY CHENG-HO, LEARY REBECCA, ANGENENDT PHILIPP, PAPADOPOULOS NICKOLAS, VELCULESCU VICTOR, PARMIGIANI GIOVANNI, KARCHIN RACHEL, JONES SIAN, YAN HAI, BIGNER DARELL, KUAN CHIEN-TSUN, RIGGINS GREGORY] US;

[Bert Vogelstein, Kenneth W. Kinzler, D. Williams Parsons, Xiaosong Zhang, Jimmy Cheng-Ho Lin, Rebecca J. Leary, Philipp Angenendt, Nickolas Papadopoulos, Victor Velculescu, Giovanni Parmigiani, Rachel Karchin, Sian Jones, Hai Yan, Darell Bigner, Chien-Tsun Kuan, Gregory J. Riggins] US MD Baltimore We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.

[HOHEISEL, Jörg, ANGENENDT, Philipp] Im Neuenheimer Feld 280 69120 Heidelberg;C/o Deutsches Krebsforschungszentrum German Cancer Research Center Technology Transfer Office Im Neuenheimer Feld 280 69120 Heidelberg;6 Sunny Meadow Court #301 Baltimore, MD The present invention provides a genome-wide methodology for identifying single nucleotide polymorphisms and mutations related to disease conditions, such as cancer. Specifically, the invention provides methods for detecting genome-wide mutations by successively amplifying sequence differences between two sample populations.