[SHEN, Jianhua, JIANG, Hualiang, SHEN, Xu, ZUO, Jianping, LUO, Xiaomin, BAI, Donglu, SHEN, Jingkang, CHEN, Kaixian, GUI, Chunshan, CHEN, Lili, CHEN, Jing, YANG, Yifu, ZHUANG, Xianhan, YANG, Yiming, HE, Xuchang, LIU, Hong, XIONG, Bing, LUO, Haibin, SUN, Tao, YE, Fei] 555 Chong Zhi Rd. Shanghai 201203;5th Floor, 1043 Ha Lei Rd. Shanghai 201203;Shanghai Institute of Materia Medica, Chinese Acad emy of Sciences 555 Zu Chong Zhi Rd. Shanghai 201203;Shanghai Institute of Materia Medica, Chinese Acad emy of Sciences 555 Zu Chong Zhi Rd. Shanghai 201203;Shanghai Institute of Materia Medica, Chinese Acad emy of Sciences 555 Zu Chong Zhi Rd. Shanghai 201203;Shanghai Institute of Materia Medica, Chinese Acad emy of Sciences 555 Zu Chong Zhi Rd. Shanghai 201203;Shanghai Institute of Materia Medica, Chinese Acad emy of Sciences 555 Zu Chong Zhi Rd. Shanghai 201203;Shanghai Institute of Materia Medica, Chinese Acad emy of Sciences 555 Zu Chong Zhi Rd. Shanghai 201203;Shanghai Institute of Materia Medica, Chinese Acad emy of Sciences 555 Zu Chong Zhi Rd. Shanghai 201203;Shanghai Institute of Materia Medica, Chinese Acad emy of Sciences 555 Zu Chong Zhi Rd. Shanghai 201203;Shanghai Institute of Materia Medica, Chinese Acad emy of Sciences 555 Zu Chong Zhi Rd. Shanghai 201203;Shanghai Institute of Materia Medica, Chinese Acad emy of Sciences 555 Zu Chong Zhi Rd. Shanghai 201203;Shanghai Institute of Materia Medica, Chinese Acad emy of Sciences 555 Zu Chong Zhi Rd. Shanghai 201203;Shanghai Institute of Materia Medica, Chinese Acad emy of Sciences 555 Zu Chong Zhi Rd. Shanghai 201203;Shanghai Lead Discovery Pharmaceuticals Limited Co mpany 5th Floor, 1043 Ha Lei Rd. Shanghai 201203;Shanghai Institute of Materia Medica, Chinese Acad emy of Sciences 555 Zu Chong Zhi Rd. Shanghai 201203;Shanghai Institute of Materia Medica, Chinese Acad emy of Sciences 555 Zu Chong Zhi Rd. Shanghai 201203;Shanghai Institute of Materia Medica, Chinese Acad emy of Sciences 555 Zu Chong Zhi Rd. Shanghai 201203;Shanghai Institute of Materia Medica, Chinese Acad emy of Sciences 555 Zu Chong Zhi Rd. Shanghai 201203;Shanghai Institute of Materia Medica, Chinese Acad emy of Sciences 555 Zu Chong Zhi Rd. Shanghai 201203;Shanghai Institute of Materia Medica, Chinese Acad emy of Sciences 555 Zu Chong Zhi Rd. Shanghai 201203;Shanghai Institute of Materia Medica, Chinese Acad emy of Sciences 555 Zu Chong Zhi Rd. Shanghai 201203 The present invention discloses 3D-structure of SARS-CoV Viruses 3CL Protease obtained through molecular modeling: The 3D-structure can be used as a target for screening medical database CMC (Comprehensive Medicinal Chemistry, MDL Information System, Inc.), discovering a group of compounds which have activity of inhibiting SARS-CoV viruses 3CL Protease. Cinanserin is assayed on molecular and viruse levels, discovering that it has better activity of inhibiting SARS-CoV viruses 3CL Protease and it has anti-SARS-CoV viruses activity. Cinanserin analogs are synthesized. We did assay on molecular and viruses levels, discovering that they have activity of inhibiting SARS-CoV viruses 3CL Protease and they have anti-SARS-CoV viruses activity, which can be used for treating and/or preventing SARS-CoV viruses infection.

[WANG, Wenhui, WANG, Youqi, WANG, Guilin, ZHENG, Xiaochun, XU, Yonghua, WANG, Wenge, ZHAO, Xianzhong, XU, Sibiao, DIAO, Lichen, XU, Xixiang, SHEN, Wenhu, WANG, Yinrui, CHEN, Bin] West first floor, Building #5 3000 Longdong Avenue, Zhangjiang High-tech Park, Pudong Shanghai 201203;221 B Conant Road Rochester, New York 14623;2471 E. Bayshore Road, Suite 520 Palo Alto, California 94303;Room 801 No.15, Lane 798, Zhenguang Road, Putuo District Shanghai 200335;Room 706 No. 41, Lane 50, Pingyang Road, Minhang District Shanghai 201102;Room 206 No.5, Tianlin Community 14, Xuhui District Shanghai 200233;Room 302 No. 9, Lane 199, Xiangnan Road, Pudong New Area District Shanghai 201203;Room 201 No. 29, Lane 60, Zhonghuamei Road, Minhang District Shanghai 201106;Room 502 No. 1, Lane 415, Middle Yingyuan Road, Jiading District Shanghai 201800;Room 102 No. 48, Lane 39, Xiangnan Road, Pudong New Area District Shanghai 201203;Room 302 No. 15, Lane 1390, Lingshan Road, Pudong New Area District Shanghai 200135;No.31 Lane 1143, East Yuhang Road, Hongkou District Shanghai 200082;Room 603 No.157, Huanghua Road, Minhang District Shanghai 201103;Room 502 No.501, Kongjiang Road, Yangpu District Shanghai 200093 A valve according to one embodiment of the present invention comprises a valve body and a valve core. The valve body has a chamber and a plurality of fluid passages each having a first fluid port opening to the chamber and a second fluid port for connecting to a corresponding external device. The valve core can be operated to move in the chamber. The valve further comprises a first sealing element to prevent leakage of fluid through a valve opening and at least one second sealing element to separate a space formed between the valve body and the valve core into areas. Each area accommodates at least one first fluid port for leading fluid into the areas from a corresponding external device, so that a fluid pressure difference between two sides of each second sealing element is lower than a fluid pressure on at least one side of the second sealing element.

[ZHAO, Xinxian, XU, Jun, XU, Shuyun, WEI, Wei, XU, Jijian, YANG, Zhengqi, LIANG, Yi, WANG, Zheng] 4002 Huaqiang Road North. Shenzhen Guangdong 518028;Shen zhen lansen medicine co. ltd. 4002 Huaqiang Road North. Shenzhen Guangdong 518028;Shen zhen lansen medicine co. ltd. 4002 Huaqiang Road North. Shenzhen Guangdong 518028;Shen zhen lansen medicine co. ltd. 4002 Huaqiang Road North. Shenzhen Guangdong 518028;Shen zhen lansen medicine co. ltd. 4002 Huaqiang Road North. Shenzhen Guangdong 518028;Shen zhen lansen medicine co. ltd. 4002 Huaqiang Road North. Shenzhen Guangdong 518028;Shen zhen lansen medicine co. ltd. 4002 Huaqiang Road North. Shenzhen Guangdong 518028;Shen zhen lansen medicine co. ltd. 4002 Huaqiang Road North. Shenzhen Guangdong 518028;Shen zhen lansen medicine co. ltd. 4002 Huaqiang Road North. Shenzhen Guangdong 518028 This invention discloses the use of total glucosides peony of producing a medicament which can treat or prevent from primary sicca syndrome, Behcet's disease, pulmonary interstitial fibrosis, fibromuscular pain syndrome, ankylosing spondylitis, liver fibrosis, systemic lupus erythematosus and so on.

[Manhua Zhang, Shangjie Xu, Tao Wu, Shen Chen, Tao Shen] CN Beijing The invention involves a methods and compositions for use in photodynamic therapy. Novel perylenequinone derivatives, conjugates comprising perylenequinone derivatives and a binding agent, and methods of treatment using these compositions are disclosed. The present invention relates to the field of photosensitizers possessing photodynamic activities. They possess high photodynamic activities and low dark toxicities, which makes them as more potent photodynamic agents than HPD against cancer and AIDS virus.

[Qirong Shen, Yanxia Liu, Xingming Yang, Yangchun Xu, Biao Shen] CN Nanjing The present invention relates to the antagonistic bacteria that are used to prevent and eliminate tobacco bacterial wilt and their microbial organic fertilizer, which belong to the technology for agricultural intensive production. The present invention separates two antagonistic bacteria (Brevibacillus brevis NJL-25 and Bacillus cereus NJL-14) that have remarkable antagonistic action against the pathogens of tobacco bacterial wilt. Microbial organic fertilizer is produced from these antagonistic bacteria and organic compost. Wherein, the content of each of NJL-25 and NJL-14 is above 1×1010 cfu/g, the content of total nitrogen is 4˜5% (above 90% of the nitrogen is organic nitrogen), the content of total nitrogen-phosphorus-kalium nutrient is 6˜10% and the content of organic matter is 30˜35%. As indicated by experiments, after the microbial organic fertilizer is applied into soil, it will enable rapid multiplication of the antagonistic bacteria into a dominant microflora in the soil and achieve more than 97.6% of biocontrol rate of tobacco bacterial wilt in the soil suffering from tobacco bacterial wilt. If the microbial organic fertilizer is applied in the soil without continuous cropping obstacle in a long time, it can prevent the occurrence of the bacterial wilt of continuous cropping tobacco to a great extent.

[SHEN, Qirong, LIU, Yanxia, YANG, Xingming, XU, Yangchun, SHEN, Biao] No.1 Weigang Nanjing, Jiangsu 210095;A Zone, Environmental Protection Technology Park Yixing, Jiangsu 214200;No.1 Weigang Nanjing, Jiangsu 210095;No.1 Weigang Nanjing, Jiangsu 210095;No.1 Weigang Nanjing, Jiangsu 210095;No.1 Weigang Nanjing, Jiangsu 210095;No.1 Weigang Nanjing, Jiangsu 210095 Antagonistic bacteria for preventing and treating bacterial wilt disease of continuously planted tobacco and microorganism organic fertilizer thereof are disclosed, wherein the antagonistic bacteria are isolated Brevibacillus brevis NJL-25 and Bacillus cereus NJL-14 with significant antagonisms towards Ralstonia solanacearum. The microorganism organic fertilizer is produced from such antagonistic bacteria strains and organic compost. The fertilizer comprises more than 1×1010 cells/g of NJL-25 and NJL-14, respectively. In the fertilizer, mass ratio of total nitrogen is 4-5% (wherein mass ratio of organic nitrogen is more than 90%); mass ratio of total nitrogen, phosphorus and potassium nutrients is 6-10%; and mass ratio of organic material is 30-35%. Experiments show that the antagonistic bacteria can quickly propagate to form dominant population in the soil after the microorganism organic fertilizer is applied into the soil, and the biological preventing and treating rate on the bacterial wilt disease in the soil affected by tobacco bacterial wilt disease is more than 97.6%. Applying the microorganism organic fertilizer into the soil without continuously planting obstacle for a long time can prevent the occurrence of bacterial wilt disease of continuously planted tobacco to a great degree.

[YANG, Baoyi, WU, Binghua, XU, Huaiyuan, ZHU, Zhengxue, SHEN, Yubin, WANG, Xuegang, YANG, Liqiang, WANG, Jialiang, JIANG, Wenhui, BAO, Shengqiang, SHENG, Xiaolin, SHEN, Xiaoqin] Economic Zone, Gaoqiao Town, Tongxiang Zhejiang 314515;No.7,Unit 2, Building 6,Qingshui Community Yatai New Vllage, No.362,Lianfang Road Congtai District, Handan Hebei 056004;Room 305, Building 19, Jiuqu Community, Wutong Street Tongxiang, Zhejiang 314500;Room20, Building 5, No.2555, Lushanzhong Road Economic-Technological, Deveoment Area Nanchang, Jiangxi 330013;Room 202, Building 1, Beimenzhi Street, Wutong Street, Tongxiang Zhejiang 314500;Government Dorm, Lingan Town, Jiuqu Community Wutong Street, Tongxiang Zhejiang 314500;No. 351, Nongfeng Road, Xiashi Street, Haining Zhejiang 314400;No.1, Zhicun Street, Chongfu Town, Tongxiang Zhejiang 314511;No. 15, Yima Road, Zhouquan Town, Tongxiang Zhejiang 314513;No. 11, Row 5, Xiangyang Street, Tuguiwula Town Chaha'er Youqi Qianqi, Wulanchabu Inner Mongolia 012200;No. 19, Baojia Corner, Chengxia Village, Wutong Street, Tongxiang Zhejiang 314500;No. 47, Yangyan Bridge, New Village, Tongfu Town Tongxiang, Zhejiang 314505;No. 142, Renmin Street, Nanguan District Changchun, Jilin 130022 Method for post-extracting low-acyl gellan gum comprises steps: deacetylating of gellan gum fermentation broth, enzyme treating, flocculating the low-acyl gellan gum with bivalent or multivalent metal cations, clarifying the gellan gum solution, dewatering the gellan gum solution, removing bivalent or multivalent cations and decoloring, and drying and crushing. As preferred, chelating agent/acid system of appropriate amount may be also added before the step of drying and crushing, so as to chelate bivalent cations which may be introduced additionally in the use of gellen gum, and keep pH in relatively stable value at the same time. Various low-acyl gellan gums prepared by above method are also provided, which have features of good appearance, high transmittance, high gel strength, and have specific performance of color value of more than 83%, transmittance of more than 85%, and gel strength of more than 400g/ cm2.

[SHEN MING-YOU, SHEN WEI-LIN, ZHENG XU-DONG, XIE JUN-SEN] TW;TW;TW;TW A monitoring method for water network is disclosed, including the following steps: establishing a first water power modeling data based on the water demands of each district in a water network allocation map and attribute data of pipe-network elements; obtaining monitoring data for particular locations in the water network at different time segments in different seasons, and comparing it with the first water power modeling data, thereby adjusting the first water power modeling data to obtain a water power modeling database having a plurality of second water power modeling data. The disclosed method then is able to access a second water power modeling data based on current season and time segment so as to compare the data with the monitored data, and then send out alarm signal if the outcome of comparison is abnormal. Accordingly, the disclosed method provides a more accurate outcome for the comparison between the water power modeling data and the monitored data for the water network.

[SHEN, Wenbiao, HUANG, Liqin, SHEN, Jinliang, LING, Tengfang, XUAN, Wei, XU, Sheng, YE, Maobing, SHAO, Suning, HUANG, Benkai, GU, Keyu, LIU, Kaili, LIU, Yahui, CAO, Zeyu, SA, Zhisheng, HAN, Yi, XIE, Yanjie, LIU, Hui] No.1 Weigang Nanjing, Jiangsu 210095;No.1 Weigang Nanjing, Jiangsu 210095;No.1 Weigang Nanjing, Jiangsu 210095;No.1 Weigang Nanjing, Jiangsu 210095;No.1 Weigang Nanjing, Jiangsu 210095;No.1 Weigang Nanjing, Jiangsu 210095;No.1 Weigang Nanjing, Jiangsu 210095;No.1 Weigang Nanjing, Jiangsu 210095;No.1 Weigang Nanjing, Jiangsu 210095;No.1 Weigang Nanjing, Jiangsu 210095;No.1 Weigang Nanjing, Jiangsu 210095;No.1 Weigang Nanjing, Jiangsu 210095;No.1 Weigang Nanjing, Jiangsu 210095;No.1 Weigang Nanjing, Jiangsu 210095;No.1 Weigang Nanjing, Jiangsu 210095;No.1 Weigang Nanjing, Jiangsu 210095;No.1 Weigang Nanjing, Jiangsu 210095;No.1 Weigang Nanjing, Jiangsu 210095 The present invention provides a plant growth regulator containing hemin, belonging to the field of development and utilization of plant growth regulator. The applying method comprises irrigating, spraying or immersing plants, plant organs and seeds with the plant growth regulator in which the final concentration of hemin is 0.001-1000mM. The application continues for 1-60 days, and 1-3 times per day. Such application can promote growth and evocation of plants, accelerate germination of seeds, enhance oxidation resistance, and improve stress resistance or tolerance. Owing to the low price of hemin and the related metabolic mechanism in vivo,such method possesses such advantages as no pollution, low cost and wide range of application, which make it applicable for chemical regulation and control of farmland, provenance agriculture, tissue culture, storage of fruits and vegetables, and preservation of cut flowers.

[JIANG, Hualiang, SHEN, Xu, SHEN, Jianhua, LIU, Hong, LUO, Xiaomin, GUI, Chunshan, LI, Jian, GUO, Hongxia, LI, Chenjing, CHEN, Kaixian] 555 Zu Chong Zhi Road Pudong New District Shanghai 201203;555 Zu Chong Zhi Road Pudong New District Shanghai 201203;555 Zu Chong Zhi Road Pudong New District Shanghai 201203;555 Zu Chong Zhi Road Pudong New District Shanghai 201203;555 Zu Chong Zhi Road Pudong New District Shanghai 201203;555 Zu Chong Zhi Road Pudong New District Shanghai 201203;555 Zu Chong Zhi Road Pudong New District Shanghai 201203;555 Zu Chong Zhi Road Pudong New District Shanghai 201203;555 Zu Chong Zhi Road Pudong New District Shanghai 201203;555 Zu Chong Zhi Road Pudong New District Shanghai 201203;555 Zu Chong Zhi Road Pudong New District Shanghai 201203 The present invention provides small-molecule 1,4-di substituted benzene compounds as non-peptide ligands of cyclophilin A, which have the structure as general formula I. By biological activity tests, it has been indicated that the compounds according to the present invention have relatively strong combining capacity with cyclophilin A, thereby it is proved that the mechanism of action is to induce immunodepression. The present invention also provides the process of preparing the said compounds.